Factors elevating liver tyrosine: 2-oxoglutarate aminotransferase activity in tumor-bearing mice.

ln the later stage of tumor-bearing mice, the activity of liver tyrosine: 2・oxo・ glutarate aminotransferase was markedly elevated, whereas no particular change was noted in liver tyrosine : pyruvate aminotransferase activity. Adrenalectomy abolished the elevation of tyrosine: 2-oxoglutarate aminotransferase activity in tumor-bearers. In tumor-bearing mice, liver glycogen level was lowered in contrast to increased tyrosine : 2・oxoglutarateaminotransferase activity. Increased activity of the enzyme was reversed by glucose feeding. Increased activity of the enzyme in tumor-bearing mice was tentatively related to protein catabolism, conversion of protein to carbohydrate in the liver of the host under carbohydrate deficiency, and its possible relation to cancer cachexia was discussed.